First Description of Tumor Vascularization:
Goldman E. The growth of malignant disease in man and the lower animals with special reference to the vascular system. Lancet 1907; ii: 1236-1240.

Seminal Hypothesis:
Folkman J. Tumor angiogenesis: therapeutic implications. New England Journal of Medicine 1971; 285: 1182-1186.

Early Discoveries:
Folkman J, Merler E, Abernathy C, Williams G. Isolation of a tumor factor responsible for angiogenesis. Journal of Experimental Medicine 1971; 133:(2): 275-288.

Gimbrone MA, Leapman S, Cotran RS, Folkman J. Tumor dormancy in vivo by prevention of neovascularization. Journal of Experimental Medicine 1972; 136 (2): 261-276.

Folkman J, Hochberg M. Self-regulation of growth in three dimensions. Journal of Experimental Medicine 1973; 138(4): 745-753.

Gimbrone MA, Cotran RS, Leapman SB, Folkman J. Tumor growth and neovascularization: an experimental model using the rabbit cornea. Journal of the National Cancer Institute 1974; 52(2): 413-427.

Orlidge A, D'Amore PA. Inhibition of capillary endothelial cells by pericytes and smooth muscle cells. Journal of Cell Biology 1987; 105: 1455-1462.

Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989; 246(4935): 1306-1309.

Plouet J, Schilling J, Gospodarowicz D. Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT-20 cells. EMBO Journal 1989; 8(12): 3801-3806.

First Angiogenesis Growth Factor:
Shing Y, Folkman J, Sullivan R, Butterfield C, Murray J, Klagsbrun M. Heparin affinity: purification of a tumor-derived capillary endothelial cell growth factor. Science 1984; 223 (4642): 1296-1299.

First Angiogenesis Inhibitor:
Brem H, Folkman J. Inhibition of tumor angiogenesis mediated by cartilage. Journal of Experimental Medicine 1975; 141:

First Clinical "Proof of Concept" of Antiangiogenic Therapy for Tumors:
White CW, Sondheimer HM, Crouch EC, Wilson H, Fan LL. Treatment of pulmonary hemangiomatosis with recombinant interferon alfa-2a. New England Journal of Medicine 1989; 320(18): 1197-1200.

Folkman J. Successful treatment of an angiogenic disease. New England Journal of Medicine 1989; 320(18): 1211-1212.

First Clinical "Proof of Concept" of Pro-angiogenic Therapy for the Ischemic Heart:
Schumacher B, Pecher P, von Specht BU, Stegmann T. Induction of neoangiogenesis in ischemic myocardium by human growth factors: first clinical results of a new treatment of coronary heart disease. Circulation 1998;97(7):645-650.

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