Known Angiogenic Growth Factors
Angiogenin
Angiopoietin-1
Del-1
Fibroblast growth factors:
acidic (aFGF) and basic (bFGF)
Follistatin
Granulocyte colony-stimulating
factor (G-CSF)
Hepatocyte growth factor
(HGF) /scatter factor (SF)
Interleukin-8 (IL-8)
Leptin
Midkine
Placental growth factor
Platelet-derived endothelial
cell growth factor (PD-ECGF)
Platelet-derived growth
factor-BB (PDGF-BB)
Pleiotrophin (PTN)
Progranulin
Proliferin
Transforming growth factor-alpha
(TGF-alpha)
Transforming growth factor-beta
(TGF-beta)
Tumor necrosis factor-alpha
(TNF-alpha)
Vascular endothelial growth
factor (VEGF)/vascular permeability factor (VPF)
- Known Angiogenesis Inhibitors
- Angioarrestin
- Angiostatin (plasminogen
fragment)
- Antiangiogenic antithrombin
III
- Cartilage-derived inhibitor
(CDI)
- CD59 complement fragment
- Endostatin (collagen XVIII
fragment)
- Fibronectin fragment
- Gro-beta
- Heparinases
- Heparin hexasaccharide fragment
- Human chorionic gonadotropin
(hCG)
- Interferon alpha/beta/gamma
- Interferon inducible protein
(IP-10)
- Interleukin-12
- Kringle 5 (plasminogen fragment)
- Metalloproteinase inhibitors
(TIMPs)
- 2-Methoxyestradiol
- Placental ribonuclease inhibitor
- Plasminogen activator inhibitor
- Platelet factor-4 (PF4)
- Prolactin 16kD fragment
- Proliferin-related protein
(PRP)
- Retinoids
- Tetrahydrocortisol-S
- Thrombospondin-1 (TSP-1)
- Transforming growth factor-beta
(TGF-b)
- Vasculostatin
- Vasostatin (calreticulin
fragment)
Last updated June 23, 2009
References:
Folkman J. Antiangiogenesis Agents, in Cancer: Principles & Practice of Oncology, 6th ed. DeVita VT, Hellman S, Rosenberg SA, eds. Lippincott Williams & Wilkins, Philadelphia, PA, 2001, pp.509-519.
Folkman J, Klagsbrun M. Angiogenic factors. Science 1987;235:442-447.
Kerbel RS, Molecular Origins of Cancer, Tumor Angiogenesis. N Engl J Med 2008;358:2039-2049.
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